Chemical Structure / July 18, 2018 / Charley Middleton
Benzylamine occurs biologically from the action of the N-substituted formamide deformylase enzyme, which is produced by Arthrobacter pascens bacteria. This hydrolase catalyses the conversion of N-benzylformamide into benzylamine with formate as a by-product. Benzylamine is degraded biologically by the action of the monoamine oxidase B enzyme, resulting in benzaldehyde.
Mono acyl derivative of o-phenylenediamine is readily converted into the corresponding benzimidazole by the action of heat alone. These conversions are generally carried out at a temperature somewhat above the melting point of the starting compounds. This is a convenient method for preparing benzimidazoles when monoacyl derivatives are easily obtainable. The procedure may be improved by heating the monoacyl derivative of diamine in an atmosphere of nitrogen to prevent oxidation (Kelly, 1945).
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