Chemical Structure / August 8, 2018 / Azalea Mccarty
In organic synthesis, benzyl chloride is used for the introduction of the benzyl protecting group in reaction with alcohols, yielding the corresponding benzyl ether, carboxylic acids, and benzyl ester. Benzoic acid (C6H5COOH) can be prepared by oxidation of benzyl chloride in the presence of alkaline KMnO4.
The ammonium cation is a positively charged polyatomic ion with the chemical formula NH+4. It is formed by the protonation of ammonia (NH3). Ammonium is also a general name for positively charged or protonated substituted amines and quaternary ammonium cations (NR+4), where one or more hydrogen atoms are replaced by organic groups (indicated by R).
Sodium methoxide has been used in the preparation of 5-(3-azidopropyl) uridine. It may be used in the synthesis of methyl 2-cyano-lup-3-hydroxy-2-en-28-oate (CN-BA), a 2-cyano derivative of betulinic acid (BA). Sodium methoxide may be used as an alkali catalyst for the production of fatty acid methyl esters (biodiesel) from vegetable oils via transesterification.
Industrially, benzyl chloride is the precursor to benzyl esters which are used as plasticizers, flavorants, and perfumes. Phenylacetic acid, a precursor to pharmaceuticals, is produced from benzyl cyanide, which is generated by treatment of benzyl chloride with sodium cyanide. Quaternary ammonium salts, used as surfactants, are readily formed by alkylation of tertiary amines with benzyl chloride.
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