Chemical Structure / July 16, 2018 / Mckenna Osborn
NMR spectra are unique, well-resolved, analytically tractable and often highly predictable for small molecules. Different functional groups are obviously distinguishable, and identical functional groups with differing neighboring substituents still give distinguishable signals. NMR has largely replaced traditional wet chemistry tests such as color reagents or typical chromatography for identification. A disadvantage is that a relatively large amount, 2–50 mg, of a purified substance is required, although it may be recovered through a workup. Preferably, the sample should be dissolved in a solvent, because NMR analysis of solids requires a dedicated magic angle spinning machine and may not give equally well-resolved spectra.
Methylene Chloride is a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of pharmaceuticals, as a degreasing agent, in electronics manufacturing and as an ethane foam blowing agent. Inhalation exposure to this substance irritates the nose and throat and affects the central nervous system. Methylene chloride is a possible mutagen and is reasonably anticipated to be a human carcinogen.
Sodium permanganate is a purplish colored crystalline solid. Noncombustible but accelerates the burning of combustible material. If the combustible material is finely divided the mixture may be explosive. May spontaneously ignite in contact with liquid combustible materials. Contact with sulfuric acid may cause fires or explosions. Used in medicine, as a disinfectant, and for many other uses.
Acetyl chloride is produced in the laboratory by the reaction of acetic acid with chlorodehydrating agents such as PCl3, PCl5, SO2Cl2, phosgene, or SOCl2. However, these methods usually gives acetyl chloride contaminated by phosphorus or sulfur impurities, which may interfere with the organic reactions.
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