Chemical Structure / July 18, 2018 / Jaelyn Herrera
Synthesis of commercially available benzimidazole involves condensation of o-phenylenediamine with formic acid. The most prominent benzimidazole compound in nature is N-riosyldimethylbenzimidazole, which serves as a axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc. The substituted benzimidazoles are summarized in this review to know about the chemistry as well as pharmacological activities.
Benzimidazole is also synthesized from o-phenylenediamine and mono or di-basic acid. In this method, the diamine is simply heated with excess acid (Fischer, 1905).This procedure has been recommended as a means of identifying fatty acid α-hydroxy acid as well as phenylacetic acid and diphenylacetic acid are converted into the corresponding benzimidazoles when heated with o-phenylenediamine.
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